Adiposity and breast, endometrial, and colorectal cancer risk in postmenopausal women: Quantification of the mediating effects of leptin, C-reactive protein, fasting insulin, and estradiol

SG Dashti; JA Simpson; V Viallon; A Karahalios; M Moreno-Betancur; T Brasky; K Pan; TE Rohan; AH Shadyab; CA Thomson; RA Wild; S Wassertheil-Smoller; GYF Ho; HD Strickler; DR English; MJ Gunter

Journal article

Adiposity and breast, endometrial, and colorectal cancer risk in postmenopausal women: Quantification of the mediating effects of leptin, C-reactive protein, fasting insulin, and estradiol

SG Dashti, JA Simpson, V Viallon, A Karahalios, M Moreno-Betancur, T Brasky, K Pan, TE Rohan, AH Shadyab, CA Thomson, RA Wild, S Wassertheil-Smoller, GYF Ho, HD Strickler, DR English, MJ Gunter

Cancer Medicine | WILEY | Published : 2022

DOI: 10.1002/cam4.4434

Download PDF

Abstract

Background: Mechanisms underlying the adiposity–cancer relationship are incompletely understood. We quantified the mediating roles of C-reactive protein (CRP), leptin, fasting insulin, and estradiol in the effect of adiposity on estrogen receptor (ER)-positive breast, endometrial, and colorectal cancer risk in postmenopausal women. Methods: We used a case–cohort study within the Women's Health Initiative Observational Study, analyzed as a cumulative sampling case–control study. The study included 188 breast cancer cases, 98 endometrial cancer cases, 193 colorectal cancer cases, and 285 controls. Interventional indirect and direct effects on the risk ratio (RR) scale were estimated using caus..

View full abstract

University of Melbourne Researchers

Ghazaleh Dashti Author

Julie Simpson Author

Emily Karahalios Author

Margarita Moreno-Betancur Author

Related Projects (2)

INTEGRATION OF BIOSTATISTICS AND MATHEMATICAL MODELLING TO IMPROVE THE CONTROL OF INFECTIOUS DISEASES

Improving the control of infectious diseases requires the evaluation of interventions that prevent disease at the population level and succe..

EXPLAINING THE CAUSAL EFFECT OF OBESITY ON COLORECTAL AND POSTMENOPAUSAL BREAST CANCER

With rising rates in Australia and globally, obesity is fast surpassing smoking to become the biggest preventable cause of cancer. While los..

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported by Australian National Health and Medical Research Council grants (1150591 to SGD and 1104975 to JAS) and Melbourne Research Scholarship (to SGD). MMB is the recipient of an Australian Research Council Discovery Early Career Award (project number DE190101326) funded by the Australian Government. Thomas Rohan is supported by the Breast Cancer Research Foundation (BCRF-19-140). The work reported in this paper was undertaken by SGD while hosted by the International Agency for Research on Cancer (IARC) and funded partially by a PhD Scholarship by IARC.